Molecular targets of organophosphorus compounds and antidotal agents on nicotinic, glutamatergic and gabaergic synapses. Appendix 1. Final report
There are several major motivators behind this work. We need to understand OP intoxication sufficiently to provide insight and direction for development of improved antidotal therapy. The persistent environmental use of chemical insecticides, which some feel is necessary for optimal agricultural production but others challenge vehemently, requires that we understand the toxicological consequences of such use. Also, OPs have such a powerful effect or, vital functions, it could be immensely beneficial to understand in great detail the physiological mechanisms that are targeted by OPs. Such information could benefit medical treatments of diseases and pathologies other than those directly caused by OPs. Finally, we hope to present the material in a manner that will be instructive to a broad spectrum of professionals in pharmacology and toxicology. Where it is appropriate, we may draw heavily from other topical reviews. In all cases, we will provide citations to original work and/or well-referenced RA I, Lab Animals, Rats, Frogs, Compounds, Nerve Agents, Organophosphorous, BD, CD Agents, XCSM, Neurotransmitters, Receptors, Ion Channel, Oximes.
- Research Organization:
- Maryland Univ., Baltimore, MD (United States). School of Medicine
- OSTI ID:
- 7239938
- Report Number(s):
- AD-A-277343/0/XAB; CNN: DAMD17-81-C-1279; DAMD17-88-C-8119
- Resource Relation:
- Other Information: Continuation of Contract DAMD17-84-C-4219
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
PHOSPHINIC ACIDS
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