Effect of methylmercury on acetylcholinestrase and serum cholinesterase activity in monkeys, Macaca fascicularis
- Inst. Superiore di Sanita, Roma (Italy)
The consumption of fish and fish-derived products is the main pathway of human exposure to methylmercury (MeHg). Methylmercury levels vary widely in fish, depending on age, size, the position of the species in the food chain, and most of all, on pollution levels. MeHg affects the Acetylcholinesterase activity (AChE) and the serum Cholinesterase activity (BChE). Histoenzymatic studies showed that 100mg Methyoxyethylmercury chloride administered for 6 days to rats caused a reduction of AChE activity in the thalamus and an increase in different parts of the nervous central system. The present study aims at verifying whether the dose permitted by F.A.O. and doses 10 and 100 fold higher affect the Cholinesterase activity in primates, and whether there is a correlation between AChE and BChE.
- OSTI ID:
- 7235855
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology; (United States), Vol. 46:5; ISSN 0007-4861
- Country of Publication:
- United States
- Language:
- English
Similar Records
Inhibition of cholinesterases by stereoisomers of Huperzine-A
Structural analysis of the asparagine-linked oligosaccharides of cholinesterases. N-linked carbohydrates of cholinesterases
Related Subjects
CARBOXYLESTERASES
ENZYME ACTIVITY
METHYLMERCURY
BIOLOGICAL EFFECTS
ACETYLCHOLINE
CHOLINESTERASE
AMINES
AMMONIUM COMPOUNDS
AUTONOMIC NERVOUS SYSTEM AGENTS
DRUGS
ENZYMES
ESTERASES
ESTERS
HYDROLASES
MERCURY COMPOUNDS
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
PARASYMPATHOMIMETICS
PROTEINS
QUATERNARY COMPOUNDS
560300* - Chemicals Metabolism & Toxicology