Maternal metallothionein and zinc after acute ethanol exposure during gestation in the rat

Conference · Wed Feb 26 04:00:00 EST 1992 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:7235769

Harris, J E ^[1]

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1. Univ. of Kansas, Kansas City (United States)

Acute exposure of the rat fetus to ethanol at critical periods can cause growth retardation and brain damage; the mechanism(s) is not known. Ethanol may cause redistribution of maternal zinc which results in fetal zinc deficiency and subsequent interruption of growth and development. The purpose was to determine if acute ethanol administration to the pregnant rat alters Zn and the Zn binding protein metallothionein (MT) in selected tissues. On gestational day (gd) 14, eighteen pregnant Sprague-Dawley rats were divided into groups. By intragastric tube, ethanol treated dams were given ethanol and pairfed controls were given a 0.85% NaCl solution. On gd 15, intragastric feedings were repeated. Throughout, the Lieber-DeCarli control diet was fed (adlibitum to untreated controls and ethanol treated dams and in appropriate quantities to pair fed controls). Blood ethanol concentrations at 90 minutes after the ethanol dose were 154 {plus minus} 46 and 265 {plus minus} 110 mg% on gd 14 and 15, respectively.

• OSTI ID: 7235769
• Report Number(s): CONF-9204141--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 6:4
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ALCOHOLS
ANIMAL GROWTH
ANIMALS
BIOSYNTHESIS
ELEMENTS
ETHANOL
FETUSES
GROWTH
HYDROXY COMPOUNDS
MAMMALS
METALLOPROTEINS
METALLOTHIONEIN
METALS
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
PREGNANCY
PROTEINS
RATS
RODENTS
SYNTHESIS
TOXICITY
VERTEBRATES
ZINC