GM1 ganglioside reduces the motor incoordination and loss of righting reflex caused by acute ethanol in C57BL/6J mice
- Texas Coll. of Osteopathic Medicine, Ft. Worth (United States)
Ethanol produces its intoxicating effects by modifying neuronal membranes. Gangliosides stabilize neuronal membranes and promote their recovery from a variety of insults. In this experiment, the efficacy of GM1(i.p.) to reverse ethanol intoxication was evaluated in male mice trained to run on a constantly accelerating rotorod. When mice were tested 15-min following saline or ethanol GM1 pre-treatment reduced rotorod performance by 15% but was ineffective in modifying the ethanol-impaired performance. However, when mice were tested at 15, 35, 55, 75, and 95 min intervals following ethanol, GM1 pre-treatments dose-dependently reduced the efficacy and duration of ethanol in producing motor incoordination. Further, GM1 given prior to ethanol significantly prolonged the time to onset of the loss of righting reflex from 1.4 to 1.9 min, and reduced the duration of the righting-reflex loss from 94 to 77 min. This GM1 effect was seen at 24 h, but not at 48 or 72 h after its administration. The blood ethanol concentration at awakening was significantly higher in 24h GM1-treated animals than in controls suggesting that the GM1 effect was not due to an alteration in ethanol clearance. These findings support the hypothesis that GM1 promotes recovery from ethanol intoxication via a neuroprotective mechanism.
- OSTI ID:
- 7235757
- Report Number(s):
- CONF-9204141-; CODEN: FAJOE
- Journal Information:
- FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 6:4; Conference: Federation of American Societies for Experimental Biology (FASEB) meeting, Anaheim, CA (United States), 5-9 Apr 1992; ISSN 0892-6638
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ETHANOL
TOXICITY
GANGLIOSIDES
BIOLOGICAL FUNCTIONS
NERVE CELLS
BIOLOGICAL RECOVERY
ACUTE EXPOSURE
CELL MEMBRANES
DOSE-RESPONSE RELATIONSHIPS
METABOLISM
MICE
ALCOHOLS
ANIMAL CELLS
ANIMALS
CARBOHYDRATES
CELL CONSTITUENTS
GLYCOLIPIDS
HYDROXY COMPOUNDS
LIPIDS
MAMMALS
MEMBRANES
ORGANIC COMPOUNDS
RODENTS
SACCHARIDES
SOMATIC CELLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology