Cholinergic aspects of cyanide intoxication

Technical Report · Thu May 13 00:00:00 EDT 1993

OSTI ID:7234879

Von Bredow, J D; Vick, J A

The acute exposure of pentobarbital anesthetized dogs to cyanide leads to a rapid increase and sudden halt in respiration accompanied by cardiovascular irregularities and extreme bradycardia which ultimately lead to cardiac arrest and death. Cardiac irregularities and cardiac arrest in the presence of cyanide induced respiratory arrest are assumed to be due to anoxia and therefore unresponsive to cardiotonic agents. Pretreatment or treatment with atropine sulfate or methyl atropine nitrate provides a marked reduction in the cardiovascular irregularities, bradycardia and hypotension. The cyanide induced cardiovascular effect can also be prevented by bilateral vagotomy. An intramuscularly injected combination of 20 mg/kg sodium nitrite and 1 mg/kg of atropine sulfate ensured recovery of pentobarbital anesthetized dogs exposed to lethal concentrations (2.5 mg/kg i.v.) of sodium cyanide.

• Research Organization: Walter Reed Army Inst. of Research, Washington, DC (United States). Div. of Experimental Therapeutics
• OSTI ID: 7234879
• Report Number(s): AD-P-008847/6/XAB
• Resource Relation: Other Information: This article is from 'Proceedings of the Medical Defense Bioscience Review (1993) Held in Baltimore, Maryland on 10-13 May 1993. Volume 2', AD-A275 668, 921-927
• Country of Publication: United States
• Language: English

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