NBQX and TCP prevent soman-induced hippocampal damage
Technical Report
·
OSTI ID:7234869
In a previous investigation we demonstrated that the measurement of w3 (peripheral-type benzodiazepine) binding site densities could be of widespread applicability in the localization and quantification of soman-induced damage in the central nervous system. We thus used this marker to assess, in mouse hippocampus, the neuroprotective activity against soman-induced brain damage of NBQX and TCP which are respective antagonists of non-NMDA and NMDA glutamatergic receptors. Injection of NBQX at 20 or 40 mg/kg 5 min prior to soman totally prevented the neuronal damage. Comparatively, TCP had neuroprotective efficacy when administered at l mg/kg 5 min prior to soman followed by a reinjection 1 hour after. These results demonstrate that both NBQX and TCP afford a satisfactory neuroprotection against soman-induced brain damage. Since it is known that the neuropathology due to soman is closely seizure-related, it is likely that the neuroprotective activities of NBQX and TCP are related to the respective roles of non-NMDA and NMDA receptors in the onset and maintenance of soman-induced seizures.
- Research Organization:
- Army Medical Research Inst. of Chemical Defense, Aberdeen Proving Ground, MD (United States)
- OSTI ID:
- 7234869
- Report Number(s):
- AD-P-008796/5/XAB
- Country of Publication:
- United States
- Language:
- English
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45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEFENSE
450600* -- Military Technology
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CHEMICAL WARFARE AGENTS
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MEDICINE
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450600* -- Military Technology
Weaponry
& National Defense-- Chemical & Biological-- (1990)
550200 -- Biochemistry
560300 -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOCHEMISTRY
CHEMICAL WARFARE AGENTS
CHEMISTRY
MEDICINE
PREVENTIVE MEDICINE
WEAPONS