Anticholinesterase therapeutics. Preparation and in vivo evaluation of side-chain substituted quaternary imidazolium salts as pretreatment agents for organophosphonate intoxication

Technical Report · Thu May 13 00:00:00 EDT 1993

OSTI ID:7234841

Harris, R N; Koolpe, G A; Sanderson, R A; Musallam, H A; Engle, R R

Several quaternary imidazolium salts of the general formula 1 below, with R = CH3 or CH=NOH, n = 1 or 2, and X = sulfonamide, sulfamide, amide, urea, carbamate, or phosphonamide substituent were prepared, characterized, and evaluated intramuscularly in the mouse as pretreatment agents for protection against soman. Many of the compounds exhibited activity that was comparable to or better than pyridostigmine in the 15- to 60-minute pretreatment regimen indicating a rapid onset of protection. The analog of 1 with X = (N,N-dimethylamino)carbonyloxy provided significant protection at the 120 min time point distinguishing this substituent from the others and identifying it for further study.

• Research Organization: SRI International, Menlo Park, CA (United States)
• OSTI ID: 7234841
• Report Number(s): AD-P-008807/0/XAB; CNN: DAMD17-90-C-0020
• Resource Relation: Other Information: This article is from 'Proceedings of the Medical Defense Bioscience Review (1993) Held in Baltimore, Maryland on 10-13 May 1993. Volume 2', AD-A275 668, p511-513
• Country of Publication: United States
• Language: English

Related Subjects

45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEFENSE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CHEMICAL WARFARE AGENTS
PREVENTIVE MEDICINE
MEDICINE
WEAPONS
450600* - Military Technology
Weaponry
& National Defense- Chemical & Biological- (1990)
560300 - Chemicals Metabolism & Toxicology
550200 - Biochemistry