Interactions of benzo(a)pyrene with mouse epithelial cells in culture
Technical Report
·
OSTI ID:7233991
Results are reported from studies on the machanisms of the toxicity of Benzo(a)pyrene (BaP) to a mouse liver epithelial cell line (NMuLi) in culture. The toxicity and growth inhibition effects of the carcinogen were exponential with the time of exposure to BaP, with BaP concentration, and with the number of cell divisions in the presence of the carcinogen. Levels of aryl hydrocarbon hydroxylase (AHH), the enzyme responsible for metabolizing BaP to its toxic and mutagenic derivatives, were 1 to 3 times greater in log phase cells than in confluent cells. An activated derivative of BaP, the diol-epoxide, was 130 times more toxic to exponentially growing cells than to confluent cells.
- Research Organization:
- California Univ., Berkeley (USA). Lawrence Berkeley Lab.
- DOE Contract Number:
- W-7405-ENG-48
- OSTI ID:
- 7233991
- Report Number(s):
- LBL-5384
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BENZOPYRENE
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
CELL CULTURES
CELL PROLIFERATION
CONDENSED AROMATICS
ENZYMES
EPITHELIUM
HYDROCARBONS
KINETICS
METABOLISM
ORGANIC COMPOUNDS
PATHOGENESIS
REACTION KINETICS
TISSUES
TOXICITY
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BENZOPYRENE
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
CELL CULTURES
CELL PROLIFERATION
CONDENSED AROMATICS
ENZYMES
EPITHELIUM
HYDROCARBONS
KINETICS
METABOLISM
ORGANIC COMPOUNDS
PATHOGENESIS
REACTION KINETICS
TISSUES
TOXICITY