Cytarabine: cytocidal effect on normal and leukemic lymphocytes. Synergism with x-rays and comparison with mechlorethamine

Journal Article · Thu Jan 01 00:00:00 EST 1976 · Exp. Mol. Pathol.; (United States)

DOI:https://doi.org/10.1016/0014-4800(76)90059-9· OSTI ID:7226225

Schrek, R; Stefani, S S

To study the in vitro toxicity of cytarabine to nondividing lymphocytes from normal persons and from patients with chronic lymphocytic leukemia, the cells were incubated with the drug at 37/sup 0/C for 3 to 7 days and the number of viable lymphocytes was counted before and after incubation. Cytarabine produced a cytocidal effect on normal and leukemic lymphocytes, and the leukemic lymphocytes were more sensitive than the normal cells. Both deoxycytidine and incubation at 27/sup 0/C protected the cells from the cytotoxicity of the drug. The combination of cytarabine and x-irradiation produced a synergistic cytocidal effect of normal lymphocytes. In contrast, mechlorethamine was usually less toxic to leukemic than to normal lymphocytes and produced an additive, not a synergistic effect with x-irradiation.

• Research Organization: Veterans Administration Hospital, Hines, IL
• OSTI ID: 7226225
• Journal Information: Exp. Mol. Pathol.; (United States), Vol. 24
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DRUGS
RADIOSENSITIVITY EFFECTS
LYMPHOCYTES
BIOLOGICAL RADIATION EFFECTS
IRRADIATION
LEUKEMIA
MAN
SYNERGISM
TOXICITY
X RADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
HEMIC DISEASES
IONIZING RADIATIONS
LEUKOCYTES
MAMMALS
NEOPLASMS
PRIMATES
RADIATION EFFECTS
RADIATIONS
SOMATIC CELLS
VERTEBRATES
560151* - Radiation Effects on Animals- Man