Assignment of the human deoxycytidine kinase (DCK) gene to chromosome 4 band q13. 3-q21. 1

Journal Article · Sun Aug 01 04:00:00 EDT 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1365· OSTI ID:7225870

Stegmann, A P.A.; Honders, M W; Bolk, M W.J.; Willemze, R; Landegent, J E; Wessels, J ^[1]

---

1. Univ. of Leiden (Netherlands)

The enzyme deoxycytidine kinase (DCK) is the key enzyme of the salvage pathway for pyrimidine synthesis. It is responsible for the phosphorylation of deoxycytidine and several deoxycytidine analogues that are used as antimetabolites in the treatment of human cancers. For instance, the cytotoxic activity of 1-[beta]-D-arabinofuranosylcytosine (AraC), used in the chemotherapy of acute myeloid leukemia (AML), is dependent on its phosphorylation by DCK. The occurrence of clinical AraC resistance, which is usually marked by functional DCK deficiency, is one of the major obstacles in the successful treatment of AML. The cDNA sequence of the DCK gene was published and, more recently, mutational inactivation of the DCK gene has been described as a possible cause of DCK deficiency. In this study the authors report on the chromosomal localization of the DCK gene by means of fluorescence in situ hybridization. 6 refs., 2 figs.

• OSTI ID: 7225870
• Journal Information: Genomics; (United States), Journal Name: Genomics; (United States) Vol. 17:2; ISSN 0888-7543; ISSN GNMCEP
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
AZINES
CHEMICAL REACTIONS
CHEMOTHERAPY
CHROMOSOMES
DEOXYCYTIDINE
ENZYMES
GENES
GENETIC MAPPING
HETEROCYCLIC COMPOUNDS
HUMAN CHROMOSOMES
MAPPING
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHORYLATION
PHOSPHOTRANSFERASES
PROTEINS
PYRIMIDINES
RIBOSIDES
THERAPY
TRANSFERASES