Clinical evaluation of /sup 99m/Tc-pyridoxylideneglutamate for hepatobiliary scanning

Journal Article · Wed Dec 01 04:00:00 EST 1976 · Am. J. Surg.; (United States)

DOI:https://doi.org/10.1016/0002-9610(76)90442-6· OSTI ID:7212871

Matolo, N M; Stadalnik, R C; Wolfman, Jr, E F

Clinical evaluation of hepatobiliary scanning using /sup 99m/Tc-PG was done in twenty normal volunteers and eighty-three patients with liver and biliary tract disease. Satisfactory images of the biliary tract were obtained using small dosages of this agent. In normal humans, the agent reached the liver in 5 minutes, and the common bile duct, gallbladder, and duodenum in 10 to 20 minutes. The gallbladder was not visualized when the cystic duct was obstructed in patients with acute and chronic cholecystitis. In patients with partial common bile duct obstruction, a distended duct was visualized and there was delay in transit of radioactivity into the duodenum. With complete common bile duct obstruction, no radioactivity was seen in the biliary or gastrointestinal tracts up to 24 hours after injection. Hepatocellular disease was characterized by delayed liver clearance and delayed visualization of the biliary and gastrointestinal tracts. There were no toxic or other untoward effects in any patients.

• Research Organization: Univ. of California, Davis
• OSTI ID: 7212871
• Journal Information: Am. J. Surg.; (United States), Journal Name: Am. J. Surg.; (United States) Vol. 132:6; ISSN AJSUA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BILIARY TRACT
BODY
COUNTING TECHNIQUES
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TECHNETIUM 99
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YEARS LIVING RADIOISOTOPES