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Zinc metabolism in the rat. II. Secretion of zinc into intestine

Journal Article · · J. Appl. Physiol.; (United States)
OSTI ID:7208225
;

To determine the site or sites of the intestinal secretion of endogenous zinc in the rat and the amounts secreted with time, /sup 65/Zn was injected intravenously in adult male intact rats and in rats with in vivo ligation of the gastrointestinal tract. About 10 percent of the injected /sup 65/Zn was secreted into the gastrointestinal tract within 30 min after the intravenous injection of the /sup 65/Zn. The secretion of the injected /sup 65/Zn increased slowly to a maximum of 15.4 percent at 3 to 4 hr and then decreased to 12.0 percent at 24 hr. Although /sup 65/Zn was readily detected in all segments of the gastrointestinal tract, the principal site of secretion of /sup 65/Zn was the small intestine. The injected /sup 65/Zn is apparently secreted rather uniformly and rapidly throughout the entire length of the small intestine and may represent 80 percent or more of the total intestinal secretion of radiozinc within 2 hr after the administration of the /sup 65/Zn. The tissue uptake of injected /sup 65/Zn in the rats in decreasing order of /sup 65/Zn in concentration was the pancreas, the liver, the spleen, the femur, and the muscle.

Research Organization:
Veterans Administration Hospital, Hines, IL
OSTI ID:
7208225
Journal Information:
J. Appl. Physiol.; (United States), Journal Name: J. Appl. Physiol.; (United States) Vol. 34:1; ISSN JAPYA
Country of Publication:
United States
Language:
English

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Related Subjects

550500* -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
GLANDS
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOTOPES
LIVER
METABOLISM
MUSCLES
NUCLEI
ORGANS
PANCREAS
RADIOASSAY
RADIOISOTOPES
SCINTILLATION COUNTING
SECRETION
SKELETON
SMALL INTESTINE
SPLEEN
TISSUE DISTRIBUTION
ZINC 65
ZINC ISOTOPES