Dose-time relationship: computation of cell lethality following fractionated radiation therapy
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
The CELKIL function subprogram described is a simple FORTRAN algorithm for computing the cellular log-surviving-fraction for any treatment scheme. The surviving cell population is first calculated for each treatment fraction using a modified multi-target, or optionally an exponential-quadratic, model. The effect of cellular repopulation between fractions is computed by means of a logistic growth function. An idealized simulation of a course of fractionated radiation therapy is then effected for repeated recursive cycles of lethality and repopulation. Arguments in the subprogram include 6 parameters and 4 variates. Parameters used were the mean cellular lethal dose (D/sub 0/), extrapolation number, slope ratio, regeneration rate, repopulation limit (cell cycles) and a field-size or tumor-volume adjustment. Variates were the dose-per-fraction, number of fractions, average interval between fractions and the field or tumor diameter.
- Research Organization:
- Michael Reese Medical Center, Chicago
- OSTI ID:
- 7208151
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 4:3/4; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Journal Article
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Sat Dec 31 23:00:00 EST 1977
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· Radiat. Res.; (United States)
·
OSTI ID:7306778
Comparison between in vitro radiosensitivity and in vivo radioresponse in murine tumor cell lines. II: In vivo radioresponse following fractionated treatment and in vitro/in vivo correlations
Journal Article
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Wed Jan 31 23:00:00 EST 1990
· International Journal of Radiation Oncology, Biology and Physics; (USA)
·
OSTI ID:7025541
Related Subjects
560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
CELL KILLING
DOSE-RESPONSE RELATIONSHIPS
FRACTIONATED IRRADIATION
IRRADIATION
MATHEMATICAL MODELS
MEDICINE
NUCLEAR MEDICINE
PATIENTS
PLANNING
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURVIVAL TIME
THERAPY
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
CELL KILLING
DOSE-RESPONSE RELATIONSHIPS
FRACTIONATED IRRADIATION
IRRADIATION
MATHEMATICAL MODELS
MEDICINE
NUCLEAR MEDICINE
PATIENTS
PLANNING
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURVIVAL TIME
THERAPY