Nuclear Medicine Program progress report, quarter ending March 31, 1992

Technical Report · Wed Jul 01 04:00:00 EDT 1992

DOI:https://doi.org/10.2172/7206392· OSTI ID:7206392

Knapp, Jr, F F; Ambrose, K R; Callahan, A P; McPherson, D W; Mirzadeh, S; Hasan, A; Lambert, C R; Rice, D E

We describe the design synthesis and initial animal testing of a new iodine-131-labeled triglyceride analogue for the potential evaluation of clinical pancreatic insufficiency. The new agent is 1,2-dipalmitoyl-3-((15-p-iodophenyl)pentadecanoyl) rac-glycerol(1,2-Pal-3-IPPA). Following oral administration of the iodine-125-labeled agent to rats, 34.5+8.8% of the administered activity was excreted in the urine within one day, demonstrating that radioiodinated IPPA is absorbed in the intestine after release from the triglyceride by pancreatic lipase. The final catabolic product of IPPA is then conjugated and excreted via the urinary bladder. Urine analysis following oral administration of this new agent to patients may thus be a new, simple method for the clinical evaluation of various gastrointestinal diseases. The synthesis and the initial biological evaluation of the 3R-isomer of ({sup 125}I)IQNP are also described.

• Research Organization: Oak Ridge National Lab., TN (United States)
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 7206392
• Report Number(s): ORNL/TM-12110; ON: DE92017142
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703 -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARBOXYLESTERASES
CHEMICAL PREPARATION
CLEARANCE
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIGESTIVE SYSTEM
DISEASES
DOCUMENT TYPES
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
ENZYME ACTIVITY
ENZYMES
ESTERASES
ESTERS
EXCRETION
GLANDS
HYDROLASES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE 125
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIPASES
LIPIDS
MAMMALS
MATERIALS
MEDICINE
METABOLISM
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PANCREAS
PROGRESS REPORT
PROTEINS
RADIOISOTOPES
RATS
RODENTS
SYNTHESIS
TRIGLYCERIDES
URINE
VERTEBRATES
WASTES