Genomic organization and localization of the gene encoding human preprogalanin
- St. Vincent's Hospital, New South Wales (Australia)
- Universitaet Innsbruck (Austria)
An approximately 35-kb region of genomic DNA encoding the human preprogalanin gene including 5' and 3' flanking sequences has been cloned and characterized. Exons and flanking introns were sequenced to determine the structural organization of the gene. The gene spans 6.5 kb, with the first exon encoding only the 5' untranslated sequence. The coding region of preprogalanin and the 3' untranslated sequence is divided into five exons. Using high-resolution fluorescence in situ hybridization, the position of the single human preprogalanin gene was localized to chromosome 11q13.3-q13.5. Several oncogenes have been mapped to this region, which is also the breakpoint for the translocation t(11;14)(q13;q32) in chronic lymphocytic leukemia and diffuse B-cell lymphoma. 19 refs., 2 figs., 1 tab.
- OSTI ID:
- 7200926
- Journal Information:
- Genomics; (United States), Journal Name: Genomics; (United States) Vol. 18:3; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
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