Mapping of aldose reductase gene sequences to human chromosomes 1, 3, 7, 9, 11, and 13

Journal Article · Wed Sep 01 00:00:00 EDT 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1372· OSTI ID:7200803

Bateman, J B; Kojis, T ^[1]; Heinzmann, C; Sparkes, R S; Klisak, I; Diep, A ^[2]; Carper, D ^[3]; Nishimura, Chihiro ^[4]; Mohandas, T ^[5]

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1. Jules Stein Eye Institute, Los Angeles, CA (United States) UCLA School of Medicine, Los Angeles, CA (United States)
2. UCLA School of Medicine, Los Angels, CA (United States)
3. National Institute of Health, Bethesda, MD (United States)
4. National Institute of Health, Tokyo (Japan)
5. Harbor-UCLA Medical Center, Torrance, CA (United States)

Aldose reductase (alditol:NAD(P)+ 1-oxidoreductase; EC 1.1.1.21) (AR) catalyzes the reduction of several aldehydes, including that of glucose, to the corresponding sugar alcohol. Using a complementary DNA clone encoding human AR, the authors mapped the gene sequences to human chromosomes 1, 3, 7, 9, 11, 13, 14, and 18 by somatic cell hybridization. By in situ hybridization analysis, sequences were localized to human chromosomes 1q32-q43, 3p12, 7q31-q35, 9q22, 11p14-p15, and 13q14-q21. As a putative functional AR gene has been mapped to chromosome 7 and a putative pseudogene to chromosome 3, the sequences on the other seven chromosomes may represent other active genes, non-aldose reductase homologous sequences, or pseudogenes. 24 refs., 3 figs., 2 tabs.

• OSTI ID: 7200803
• Journal Information: Genomics; (United States), Vol. 17:3; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
REDUCTION
HUMAN CHROMOSOMES
GENETIC MAPPING
OXIDOREDUCTASES
GENES
HUMAN CHROMOSOME 1
HUMAN CHROMOSOME 13
HUMAN CHROMOSOME 14
HUMAN CHROMOSOME 18
HUMAN CHROMOSOME 3
HUMAN CHROMOSOME 7
HUMAN CHROMOSOME 9
CHEMICAL REACTIONS
CHROMOSOMES
ENZYMES
MAPPING
ORGANIC COMPOUNDS
PROTEINS
550400* - Genetics