Structure and localization of the gene encoding human peripheral myelin protein 2 (PMP2)

Journal Article · Mon Nov 01 00:00:00 EST 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1462· OSTI ID:7200740

Hayasaka, Kiyoshi; Himoro, Masato; Takada, Goro ^[1]; Takahashi, Ei-Ichi ^[2]; Minoshima, Shinsei; Shimizu, Nobuyoshi ^[3]

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1. Akita Univ. School of Medicine (Japan)
2. National Institute of Radiological Sciences, Chiba (Japan)
3. Keio Univ. School of Medicine, Tokyo (Japan)

Peripheral myelin protein 2 (PMP2) is a small, basic, and cytoplasmic lipid-binding protein of peripheral myelin. In this paper, the authors describe the cloning, characterization, and chromosomal mapping of the human PMP2 gene. The gene is about 8 kb long and consists of four exons. All exon-intron junction sequences conform to the GT/AG rule. The 5[prime]-flanking region of the gene has a TA-rich element (TATA-like box) and a single defined transcription initiation site detected by the primer extension method. The gene for human PMP2 was assigned to chromosome 8q21.3-q22.1 by spot hybridization of flow-sorted human chromosomes and fluorescence in situ hybridization. 29 refs., 4 figs., 1 tab.

• OSTI ID: 7200740
• Journal Information: Genomics; (United States), Vol. 18:2; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GENES
DNA-CLONING
HUMAN CHROMOSOME 8
GENETIC MAPPING
MEMBRANE PROTEINS
DNA SEQUENCING
CHROMOSOMES
CLONING
DNA HYBRIDIZATION
HUMAN CHROMOSOMES
HYBRIDIZATION
MAPPING
ORGANIC COMPOUNDS
PROTEINS
STRUCTURAL CHEMICAL ANALYSIS
550400* - Genetics