The D4 dopamine receptor gene maps on 11p proximal to HRAS
- Univ. of Toronto, Ontario (Canada)
- DuPont-Merck Pharmaceutical Corp., Wilmington, DE (United States)
The dopamine D4 receptor (DRD4) is of high interest in neuropsychiatric illness due to its anatomical distribution in the limbic system and its relatively high affinity for the atypical antipsychotic clozapine. Also, D4 receptors are expressed in cardiac tissue, and D4 maps in the same region as the inherited cardiac disease referred to as Long QT syndrome. DRD4 was genetically mapped near the tip of the short arm of chromosome 11, close to the oncogene Harvey-RAS (HRAS). Multipoint linkage analysis of several large families could not define the location of DRD4 proximal versus distal to HRAS, although it was evident that DRD4 was located distal to the gene for tyrosine hydroxylase (TH). A proximal localization of DRD4 relative to HRAS was thus demonstrated. The localization is inferred from a single recombination event, and additional studies on families segregating analyzed polymorphisms would be valuable. Exact order of the genes on 11p15 will greatly assist the resolving power of linkage studies in this region, as applied to neuropsychiatric diseases, as well as Long QT syndrome and Beckwith-Wiedemann syndrome.
- OSTI ID:
- 7200465
- Journal Information:
- Genomics; (United States), Journal Name: Genomics; (United States) Vol. 18:1; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CHROMOSOMES
DOPAMINE
DRUGS
GENES
GENETIC MAPPING
HUMAN CHROMOSOMES
HYDROXY COMPOUNDS
MAPPING
MEMBRANE PROTEINS
NEUROREGULATORS
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
PROTEINS
RECEPTORS
SYMPATHOMIMETICS