The D4 dopamine receptor gene maps on 11p proximal to HRAS

Journal Article · Fri Oct 01 00:00:00 EDT 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1445· OSTI ID:7200465

Petronis, A; Kennedy, J L; Van Tol, H H.M. ^[1]; Lichter, J B; Livak, K J ^[2]

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1. Univ. of Toronto, Ontario (Canada)
2. DuPont-Merck Pharmaceutical Corp., Wilmington, DE (United States)

The dopamine D4 receptor (DRD4) is of high interest in neuropsychiatric illness due to its anatomical distribution in the limbic system and its relatively high affinity for the atypical antipsychotic clozapine. Also, D4 receptors are expressed in cardiac tissue, and D4 maps in the same region as the inherited cardiac disease referred to as Long QT syndrome. DRD4 was genetically mapped near the tip of the short arm of chromosome 11, close to the oncogene Harvey-RAS (HRAS). Multipoint linkage analysis of several large families could not define the location of DRD4 proximal versus distal to HRAS, although it was evident that DRD4 was located distal to the gene for tyrosine hydroxylase (TH). A proximal localization of DRD4 relative to HRAS was thus demonstrated. The localization is inferred from a single recombination event, and additional studies on families segregating analyzed polymorphisms would be valuable. Exact order of the genes on 11p15 will greatly assist the resolving power of linkage studies in this region, as applied to neuropsychiatric diseases, as well as Long QT syndrome and Beckwith-Wiedemann syndrome.

• OSTI ID: 7200465
• Journal Information: Genomics; (United States), Vol. 18:1; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DOPAMINE
RECEPTORS
HUMAN CHROMOSOMES
GENETIC MAPPING
GENES
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CHROMOSOMES
DRUGS
HYDROXY COMPOUNDS
MAPPING
MEMBRANE PROTEINS
NEUROREGULATORS
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
PROTEINS
SYMPATHOMIMETICS
550400* - Genetics