A cooperative binomial ascertainment model
Journal Article
·
· American Journal of Human Genetics; (United States)
OSTI ID:7199518
- Institute of Cytology and Genetics, Novosibirsk (Russian Federation)
It has been shown that the classical binomial form of ascertainment, assuming a constant probability [pi] that any affected individual may become a proband for his pedigree, cannot describe a rather wide range of ascertainment procedures that might arise in practice. Some more general heuristic ascertainment formulas might then be preferred, and in this paper the authors consider the probabilistic basis for these formulas. They retain the binomial assumption of the classical scheme but allow the ascertainment probability to depend on the number of potential probands per pedigree. This probability can be expressed by an increasing or a decreasing function of that number. Various illustrations are given and situations where the [open quote]cooperative[close quote] binomial scheme should be valuable are discussed. 14 refs., 2 tabs.
- OSTI ID:
- 7199518
- Journal Information:
- American Journal of Human Genetics; (United States), Journal Name: American Journal of Human Genetics; (United States) Vol. 51:5; ISSN AJHGAG; ISSN 0002-9297
- Country of Publication:
- United States
- Language:
- English
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