Efficacy of an absorbable mesh in keeping the small bowel out of the human pelvis following surgery

Journal Article · Fri Jan 01 04:00:00 EST 1988 · Dis. Colon Rectum; (United States)

DOI:https://doi.org/10.1007/BF02552563· OSTI ID:7195188

Devereux, D F; Chandler, J J; Eisenstat, T; Zinkin, L

Patients with pelvic malignancies frequently require postoperative radiation therapy either as adjunctive or palliative treatment. Tumoricidal doses, however, are frequently associated with small-bowel damage. Animal experiments demonstrated tolerance to high-dose radiation therapy and protection from radiation enteritis by use of an absorbable polymer polyglycolic acid (PGA) that is used as an intestinal sling to elevate the small bowel away from the operated site. Sixty patients (42 with rectal carcinomas and 18 with gynecologic malignancies) underwent surgical treatment that included the intestinal sling procedure. Postoperative radiation was begun within three weeks following surgery and patients received a mean approximating 5500 rads in fractionated doses. A mean follow-up time of 28 months has not revealed a single case of radiation enteritis (by either contrast studies or physiologic studies) or PGA mesh-related complications. The authors believe that this surgical technique should be employed in patients who may require postoperative radiation treatment for pelvic malignancy.

• Research Organization: Univ. of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick (USA)
• OSTI ID: 7195188
• Journal Information: Dis. Colon Rectum; (United States), Journal Name: Dis. Colon Rectum; (United States) Vol. 31:1; ISSN DICRA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DOSES
ENTERITIS
FEMALE GENITALS
GASTROINTESTINAL TRACT
INJURIES
INTESTINES
LARGE INTESTINE
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIATION PROTECTION
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RECTUM
SIDE EFFECTS
SMALL INTESTINE
SURGERY
THERAPY
UTERUS