Dosimetric considerations relative to radionuclides for thyroid diagnosis and therapy. [/sup 125/I, /sup 123/I and /sup 99m/Tc compared with /sup 131/I]

Conference · Thu Jan 01 04:00:00 EST 1976

OSTI ID:7193111

Atkins, H L

Recent changes have occurred in the radionuclidic approach to the diagnosis and therapy of thyroid diseases. These changes have been directed toward reduction of radiation dose by the use of short-lived radionuclides for imaging and toward better control of late effects of therapy by substituting iodine-125 for iodine-131. Imaging of the thyroid is now widely performed following the administration of technetium-99m or iodine-123. Some problems exist relative to the use of technetium-99m in that the distribution of radioactivity in the thyroid is not always identical to the distribution of radioiodine. Iodine-123 represents a substantial advance over iodine-131 despite contamination of the former with small amounts of other radioiodines. The high incidence of induced hypothyroidism following iodine-131 therapy of thyrotoxicosis has spurred interest in the use of iodine-125. The biological effectiveness of iodine-125 is believed to be greater because of the high abundance of Auger electrons and possibly because of chemical effects following molecular disruption. Clinical results to date are discussed. (auth)

• Research Organization: Brookhaven National Lab., Upton, N.Y. (USA)
• OSTI ID: 7193111
• Report Number(s): BNL-21313; CONF-760444-8
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560151 -- Radiation Effects on Animals-- Man
560161 -- Radionuclide Effects
Kinetics
& Toxicology-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOSES
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL IRRADIATION
IODINE 123
IODINE 125
IODINE 131
IODINE ISOTOPES
IRRADIATION
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIONUCLIDE ADMINISTRATION
RADIOTHERAPY
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
THYROID
YEARS LIVING RADIOISOTOPES