Electrolyte transport in distal colon of sodium-depleted rats: Effect of sodium repletion

Journal Article · Thu Sep 01 04:00:00 EDT 1988 · American Journal of Physiology; (USA)

OSTI ID:7191856

Turnamian, S G; Binder, H J ^[1]

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1. Yale Univ. School of Medicine, New Haven, CT (USA)

Dietary sodium depletion increases plasma aldosterone level and, as a result, induces amiloride-sensitive electrogenic sodium absorption and electrogenic potassium secretion and stimulates Na{sup +}-K{sup +}-ATPase activity in rat distal colon, while inhibiting electroneutral sodium chloride absorption. To assess the events that occur as the aldosterone-stimulated colon reverts to normal, unidirectional {sup 22}Na and {sup 36}Cl fluxes were measured under voltage-clamp conditions across isolated distal colonic mucosa of rats that were initially dietary sodium depleted for 7 days and then sodium repleted for varying periods of time before the study. Within 8 h of dietary sodium repletion, plasma aldosterone level and Na{sup +}-K{sup +}-ATPase activity declined to normal, amiloride-sensitive electrogenic sodium absorption decreased by >90%, and active electrogenic potassium secretion also decreased markedly. In contrast, electroneutral sodium chloride absorption did not completely return to levels seen in normal animals until {approximately}64-68 h. These results demonstrate that maintenance of electrogenic sodium absorption and potassium secretion are directly dependent on elevated plasma aldosterone levels. The inhibition of electroneutral sodium absorption, although initiated by excess aldosterone, persists after normalization of the plasma aldosterone level, thereby implying that the inhibition is dependent on additional factor(s).

• OSTI ID: 7191856
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 255:3; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
ACID ANHYDRASES
ADRENAL HORMONES
ALDEHYDES
ALDOSTERONE
ALKALI METAL COMPOUNDS
ALKALI METAL ISOTOPES
ANIMALS
ATP-ASE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOASSAY
BODY
CHARGED PARTICLES
CHLORINE 36
CHLORINE ISOTOPES
CORTICOSTEROIDS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DIURETICS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENZYMES
GASTROINTESTINAL TRACT
HYDROLASES
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
INTESTINES
IODINE 125
IODINE ISOTOPES
IONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KETONES
LARGE INTESTINE
LIGHT NUCLEI
MAMMALS
MEMBRANE TRANSPORT
MINERALOCORTICOIDS
NUCLEI
NUTRITIONAL DEFICIENCY
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHOSPHOHYDROLASES
PHYSIOLOGY
PREGNANES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
RADIOISOTOPES
RATS
RODENTS
SECRETION
SODIUM 22
SODIUM COMPOUNDS
SODIUM ISOTOPES
STEROIDS
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES