Chronic estradiol treatment increases ovariectomized rat striatal D-1 dopamine receptors

Journal Article · Sat Dec 31 23:00:00 EST 1988 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(89)90522-5· OSTI ID:7191714

Levesque, D; de Paolo, T ^[1]

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1. Laval Univ., Sainte-Foy, Quebec (Canada)

Striatal D-1 dopamine (DA) receptors were investigated following chronic 17{beta}-estradiol to ovariectomized (OVX) female rats. This treatment initiated the day after ovariectomy has revealed that the maximal density in homogenates of striatal D-1 DA receptors (Bmax) labelled with ({sup 3}H)SCH 23390 was increased. Estradiol treatment initiated 2 or 4 weeks after ovariectomy did not induce D-1 DA receptor binding modifications. The affinity (Kd) of the ligand for the receptor remains unchanged by the steroid treatment while NaCl increased both the density and the affinity of ({sup 3}H)SCH 23390 binding to striatal D-1 DA receptors. By autoradiography, the increase of striatal ({sup 3}H)SCH 23390 binding to D-1 DA receptors after chronic estradiol treatment was found to be homogeneously distributed in this brain region. Thus, chronic treatment with estradiol of ovariectomized rats leads to an increased density of striatal D-1 DA receptors but, this hormonal modulation of D-1 DA receptors is lost when treatment is started 2 weeks after ovariectomy or later.

• OSTI ID: 7191714
• Journal Information: Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 45:19; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AFFINITY
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AUTORADIOGRAPHY
BIOCHEMICAL REACTION KINETICS
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CHRONIC EXPOSURE
DOPAMINE
DRUGS
ESTRADIOL
ESTRANES
ESTROGENS
FEMALE GENITALS
GONADS
HORMONES
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
KINETICS
LIGANDS
MAMMALS
MEDICINE
MEMBRANE PROTEINS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
OVARIES
PHENOLS
POLYPHENOLS
PROTEINS
RATS
REACTION KINETICS
RECEPTORS
RODENTS
STEROID HORMONES
STEROIDS
SURGERY
SYMPATHOMIMETICS
TRITIUM COMPOUNDS
VERTEBRATES