Cell and tissue kinetics of the subependymal layer in mouse brain following heavy charged particle irradiation

Technical Report · Thu Dec 01 04:00:00 EST 1988

DOI:https://doi.org/10.2172/7191328· OSTI ID:7191328

Manley, N B; Fabrikant, J I; Alpen, E L

The following studies investigate the cellular response and cell population kinetics of the subependymal layer in the mouse brain exposed to heavy charged particle irradiation. Partial brain irradiation with helium and neon ions was confined to one cortex of the brain. Both the irradiated and the unirradiated contralateral cortex showed similar disturbances of the cell and tissue kinetics in the subependymal layers. The irradiated hemisphere exhibited histological damage, whereas the unirradiated side appeared normal histologically. This study concerns the cell population and cell cycle kinetics of the subependymal layer in the mouse brain, and the effects of charged particle irradiations on this cell population. Quantitative high resolution autoradiography was used to study the kinetic parameters in this cell layer. This study should help in understanding the effects of these high-energy heavy ions on normal mammalian brain tissue. The response of the mammalian brain exposure to charged particle ionizing radiation may be extremely variable. It varies from minimal physiological changes to overt tissue necrosis depending on a number of factors such as: the administered dose, dose-rate, the volume of the irradiated tissue, and the biological end-point being examined.

• Research Organization: Lawrence Berkeley Lab., CA (USA)
• Sponsoring Organization: DOE/ER
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 7191328
• Report Number(s): LBL-28554; ON: DE90011327
• Country of Publication: United States
• Language: English

Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AUTORADIOGRAPHY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CELL DIFFERENTIATION
CELL PROLIFERATION
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
CHARGED PARTICLES
ELEMENTS
FLUIDS
GASES
HEAVY IONS
HELIUM
IONIZING RADIATIONS
IONS
IRRADIATION
KINETICS
LYSIS
MAMMALS
MICE
NEON
NERVOUS SYSTEM
NONMETALS
ORGANS
POPULATION DYNAMICS
RADIATION EFFECTS
RADIATIONS
RARE GASES
RODENTS
TISSUES
VERTEBRATES