New radiotherapeutic techniques in nuclear ophthalmology

Journal Article · Sun Jan 01 00:00:00 EST 1984 · Semin. Nucl. Med.; (United States)

DOI:https://doi.org/10.1016/S0001-2998(84)80054-9· OSTI ID:7190623

Fairchild, R G

Various aspects of radiotherapeutic techniques used in treating ocular tumors are discussed. Previous and current ''standard'' modalities are briefly reviewed, including beta and gamma emitters, /sup 60/Co, /sup 125/I, and charged particles. In particular, emphasis is placed upon techniques under development that use biomolecules to physiologically target radioactive or stable isotopes to ocular melanoma. These procedures include /sup 35/S-thiouracil, /sup 127/I-deoxyuridine in conjunction with irradiation with photons from /sup 145/Sm, neutron capture therapy, and various combinations of the above. Thiouracil shows particular promise because of its incorporation during melanin synthesis in growing melanoma. Radiosensitization and stimulation of Auger cascades via introduction of iodine in DNA followed by irradiation with activating photons of appropriate energy (from /sup 145/Sm) has been shown to be effective in vitro. Various molecules may be used to transport boron to ocular melanoma, including thiouracil, thus allowing selective irradiation of tumor cells via /sup 10/B (n, alpha) /sup 7/Li reaction.

• Research Organization: Brookhaven National Laboratory, Medical Department, Upton, NY
• OSTI ID: 7190623
• Journal Information: Semin. Nucl. Med.; (United States), Vol. 14:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
MELANOMAS
NEUTRON THERAPY
RADIOTHERAPY
UVEA
BORON 10
COBALT 60
DEOXYURIDINE
DOSE-RESPONSE RELATIONSHIPS
IODINE 125
IODINE 127
LITHIUM 7
MONOCLONAL ANTIBODIES
SAMARIUM 145
SULFUR 35
THIOURACIL
ALKALI METAL ISOTOPES
ANTIBODIES
ANTIMETABOLITES
ANTITHYROID DRUGS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
BORON ISOTOPES
COBALT ISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EYES
FACE
HEAD
HETEROCYCLIC COMPOUNDS
HORMONE ANTAGONISTS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIGHT NUCLEI
LITHIUM ISOTOPES
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PYRIMIDINES
RADIOISOTOPES
RADIOLOGY
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RIBOSIDES
SAMARIUM ISOTOPES
SENSE ORGANS
STABLE ISOTOPES
SULFUR ISOTOPES
THERAPY
THIOLS
URACILS
YEARS LIVING RADIOISOTOPES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)