Intact biliary excretion of gastrically administered prostaglandin F sub 2. alpha. in rats: Developmental differences

Journal Article · Tue Dec 01 04:00:00 EST 1987 · American Journal of Physiology; (USA)

OSTI ID:7190458

Bedrick, A D; Wells, M A; Ford, D L; Koldovsky, O ^[1]

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1. Univ. of Arizona Health Sciences Center, Tucson (USA)

Tritium-labeled prostaglandin F{sub 2{alpha}} was administered via orogastric tube to bile duct-cannulated suckling and weanling rats to determine if maturational differences were present in the biliary excretion of prostaglandin F{sub 2{alpha}} and metabolites. Animals were killed 2 h after radioactivity administration. Characterization of radioactivity present in bile revealed age-related differences in biliary prostaglandin F{sub 2{alpha}} excretion. Suckling rats had a greater proportion of radioactivity migrating in chromatographic regions of greater polarity than prostaglandin F{sub 2{alpha}}. Compared with the weanling, a significantly greater amount of radioactivity cochromatographed with intact, unmetabolized prostaglandin F{sub 2{alpha}}. These results indicate that orogastrically administered prostaglandin F{sub 2{alpha}} can be absorbed from the gastrointestinal tract, transported to the liver, and subsequently excreted into bile and detected in an unmetabolized form in suckling and weanling rats. The enterohepatic circulation of milk-derived prostaglandin present in bile may contribute to the overall content of intestinal prostaglandins.

• OSTI ID: 7190458
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 253:6; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
AGE DEPENDENCE
ANIMALS
BILIARY TRACT
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CHROMATOGRAPHY
CLEARANCE
DIGESTIVE SYSTEM
EXCRETION
FEMALES
FOOD
GASTROINTESTINAL TRACT
GLANDS
HYDROGEN COMPOUNDS
INTESTINAL ABSORPTION
LIVER
MAMMALS
MATERIALS
METABOLISM
METABOLITES
MILK
ORAL ADMINISTRATION
ORGANS
PROSTAGLANDINS
RADIOCHROMATOGRAPHY
RATS
RODENTS
SEPARATION PROCESSES
THIN-LAYER CHROMATOGRAPHY
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES