Prophage induction and inactivation by uv light. [Haemophilus influenzae]

Journal Article · Tue Jun 01 04:00:00 EDT 1976 · J. Virol.; (United States)

OSTI ID:7190287

Barnhart, B J; Cox, S H; Jett, J H

Analysis of the induction curves for uv light-irradiated Haemophilus influenzae lysogens and the distribution of pyrimidine dimers in a repair-deficient lysogen suggests that one dimer per prophage-size segment of the host bacterial chromosome is necessary as a preinduction event. The close correlations obtained prompted a renewed consideration of the possibility that direct prophage induction occurs when one dimer is stabilized within the prophage genome. The host excision-repair system apparently functions to reduce the probability of stabilizing within the prophage those dimers that are necessary for induction and inactivation. The presence of the inducible defective prophage in strain Rd depresses the inducibility of prophage HP1c1.

• Research Organization: Los Alamos Scientific Lab., NM
• OSTI ID: 7190287
• Journal Information: J. Virol.; (United States), Journal Name: J. Virol.; (United States) Vol. 18:3; ISSN JOVIA
• Country of Publication: United States
• Language: English

Related Subjects

560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AZINES
BACTERIA
BACTERIOPHAGES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHROMOSOMES
ELECTROMAGNETIC RADIATION
HAEMOPHILUS
HETEROCYCLIC COMPOUNDS
INACTIVATION
MICROORGANISMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARASITES
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
ULTRAVIOLET RADIATION
VIRUSES