Pulmonary distribution of particles given by intratracheal instillation or by aerosol inhalation
Journal Article
·
· Environ. Res.; (United States)
In animal studies concerned with the deposition of particulate matter in the lung, two methods for delivery of particles are commonly used, aerosol inhalation and intratracheal instillation of particle suspensions. We have attempted to evaluate the distribution patterns of each of these methods. Particles labeled with /sup 99m/Tc were administered to both rats and hamsters. The animals were subsequently killed. The lungs were excised, weighed, inflated, dried, and divided into 54 pieces which were counted individually in a Nuclear-Chicago Model 4230 Automatic Gamma Scintillation System. Groups receiving intratracheal instillations demonstrated nonuniform distribution patterns with preferential deposition in the dependent portions of the lung. The aerosol groups evidence more even distribution with preferential deposition in the apical lobes.
- Research Organization:
- Harvard Univ. School of Public Health, Boston
- OSTI ID:
- 7190201
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 11:1; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COLLOIDS
COMPARATIVE EVALUATIONS
DISPERSIONS
DISTRIBUTION
ENERGY LEVELS
EXCITED STATES
HAMSTERS
HOURS LIVING RADIOISOTOPES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MAMMALS
METASTABLE STATES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PARTICLES
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RODENTS
SOLS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COLLOIDS
COMPARATIVE EVALUATIONS
DISPERSIONS
DISTRIBUTION
ENERGY LEVELS
EXCITED STATES
HAMSTERS
HOURS LIVING RADIOISOTOPES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MAMMALS
METASTABLE STATES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PARTICLES
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RODENTS
SOLS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES