Clastogenicity evaluation of seven chemicals commonly found at hazardous industrial-waste sites
Seven chemicals commonly found at industrial waste sites were tested with the Tradescantia-micronucleus (Trad-MCN) assay to evaluate their clastogenic potential. They were: Aldrin, arsenic trioxide, 1,2-benz(a,h)anthracene, dieldrin, heptachlor, lead tetraacetate, and tetrachloroethylene. Results of repeated tests for clastogenicity yielded the minimum effective dose (MED) of 0.44 ppm for lead tetraacetate, 3.81 ppm for dieldrin, and 1.88 ppm for heptachlor. Arsenic trioxide and 1,2-benz(a,h)anthracene yielded positive responses at the MED of 3.96 ppm and 2.28 ppm, respectively. Aldrin and tetrachloroethylene were considered to be immiscible with water, and the test yielded negative responses. Results of tetrachloroethylene fume treatment yielded a positive response at the MED of 30 ppm/min in 2-hr exposures. Five chemicals determined to be clastogens by the test were ranked according to their MED in the descending order of potency as follows: Lead tetraacetate, heptachlor, 1,2-benz(a,h)anthracene, dieldrin, and arsenic trioxide. Results of the study indicate that Trad-MCN bioassay could be effectively utilized for assessing the genetic hazard from the leachates and volatile compounds emanating from uncontrolled industrial waste sites.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI ID:
- 7190061
- Report Number(s):
- PB-90-199456/XAB; EPA--600/J-89/335
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
ARSENIC
BENZANTHRACENE
BIOASSAY
CHLORINATED ALIPHATIC HYDROCARBONS
CONDENSED AROMATICS
ELEMENTS
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROCARBONS
INDUSTRIAL WASTES
LAND POLLUTION
LILIOPSIDA
MAGNOLIOPHYTA
MANAGEMENT
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PESTICIDES
PLANTS
POLLUTION
SEMIMETALS
SENSITIVITY
TOXICITY
TRADESCANTIA
WASTE DISPOSAL
WASTE MANAGEMENT
WASTES