Failure in generating hemopoietic stem cells is the primary cause of death from cytomegalovirus disease in the immunocompromised host
We have shown in a murine model system for cytomegalovirus (CMV) disease in the immunocompromised host that CMV infection interferes with the earliest detectable step in hemopoiesis, the generation of the stem cell CFU-S-I, and thereby prevents the autoreconstitution of bone marrow after sublethal irradiation. The antihemopoietic effect could not be ascribed to a direct infection of stem cells. The failure in hemopoiesis was prevented by adoptive transfer of antiviral CD8+ T lymphocytes and could be overcome by syngeneic bone marrow transplantation. CD8+ T lymphocytes and bone marrow cells both mediated survival, although only CD8+ T lymphocytes were able to limit virus multiplication in host tissues. We concluded that not the cytopathic effect of virus replication in host tissues, but the failure in hemopoiesis, is the primary cause of death in murine CMV disease.
- Research Organization:
- Federal Research Centre for Virus Diseases of Animals, Tuebingen (Germany, F.R.)
- OSTI ID:
- 7189708
- Journal Information:
- J. Exp. Med.; (United States), Vol. 167:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BONE MARROW CELLS
TRANSPLANTS
STEM CELLS
CELL DIFFERENTIATION
VIRAL DISEASES
PATHOGENESIS
BIOLOGICAL MODELS
HEMATOPOIETIC SYSTEM
LYMPHOCYTES
MICE
RADIATION CHIMERAS
SUBLETHAL IRRADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHIMERAS
CONNECTIVE TISSUE CELLS
DISEASES
INFECTIOUS DISEASES
IRRADIATION
LEUKOCYTES
MAMMALS
MATERIALS
MOSAICISM
RODENTS
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals