Beer improves copper metabolism and increases longevity in Cu-deficient rats

Journal Article · Thu Feb 09 04:00:00 EST 1989 · FASEB Journal (Federation of American Societies for Experimental Biology); (USA)

OSTI ID:7189548

Moore, R J; Klevay, L M ^[1]

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1. Dept. of Agriculture, Grand Forks, ND (USA)

Moderate consumption of alcoholic beverages decreases risk of death from ischemic heart disease (IHD). Evidence suggests that Cu-deficiency is important in the etiology and pathophysiology of IHD. The effect of beer (25 ng Cu/ml) drinking on the severity of Cu-deficiency was examined in weanling, male Sprague-Dawley rats fed a low Cu diet (0.84 {mu}g Cu/g). Beer drinking increased median longevity to 204 or 299 d from 62 or 42 d respectively in rats drinking water in two experiments (15 rats/group). In experiment 3, a single dose of {sup 67}Cu (3.3 {mu}Ci as chloride) was added to 1 g of feed and given to 12-h fasted rats 30 d after the start of the experiment. Whole body counting over 13 d showed apparent Cu absorption and t{sub {1/2}} (biological) were greater in Cu-deficient rats drinking beer than in similar rats drinking water. Plasma cholesterol was lower but hematocrit and liver Cu were higher in surviving rats drinking beer than in rats drinking water. Body weight was not affected by beer in any experiment. In experiment 4, a 4% aqueous ethanol solution had no effect on longevity of copper deficient rats. A non-alcohol component of beer alters Cu metabolism and mitigates the severity of nutritional Cu-deficiency in rats.

• OSTI ID: 7189548
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (USA), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (USA) Vol. 3:3; ISSN FAJOE; ISSN 0892-6638
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BEVERAGES
BIOLOGICAL EFFECTS
CARDIOVASCULAR DISEASES
COPPER
COPPER 67
COPPER ISOTOPES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DISEASES
ELEMENTS
ETHANOL
ETIOLOGY
FOOD
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
METABOLISM
METALS
NUCLEI
NUTRITIONAL DEFICIENCY
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
RADIOISOTOPES
RATS
RODENTS
TRANSITION ELEMENTS
VERTEBRATES
WHOLE-BODY COUNTING