NIOSH (National Institute for Occupational Safety and Health) testimony to DOL (Department of Labor) on benzene and leukemia: An epidemiologic risk assessment to the Occupational Safety and Health Administration by J. D. Millar, August 9, 1985
In the testimony, the mortality experience of a cohort with occupational exposure to benzene (71432) was updated to learn more about a possible connection to leukemia. Job/exposure matrices were used to derive cumulative exposure concentrations. The matrices were based on available air sampling data. The standardized mortality ratio (SMR) for leukemia was 328 and the SMR for multiple myeloma was 298. SMRs for leukemia increased from 105 in workers with less than 40 part per million years (ppm/y) cumulative exposure to 314 in workers with from 40 to 199.99 ppm/y; to 1,757 in those with from 200 to 399.99 ppm/y; and to 4,535 in those with 400 ppm/y or more. A 40-year working lifetime exposure at 10 parts per million was equivalent to a cumulative benzene exposure of 400 ppm/y. When the boundaries of the exposure categories were varied, this strongly positive trend in SMRs remained evident. A conditional logistic regression was performed to examine the shape of the exposure/response relation. A log linear model best explained the association between cumulative benzene exposure and leukemia. It was calculated from the model that protection against benzene induced leukemia will be increased exponentially by any reduction in the permissible exposure limit.
- Research Organization:
- National Inst. for Occupational Safety and Health, Cincinnati, OH (USA)
- OSTI ID:
- 7189289
- Report Number(s):
- PB-90-153776/XAB
- Country of Publication:
- United States
- Language:
- English
Similar Records
Benzene and leukemia. An epidemiologic risk assessment
NIOSH (National Institute for Occupational Safety and Health) testimony to DOL (Department of Labor) on OSHA (Occupational Safety and Health Administration) proposed rule for occupational exposure to benzene, by R. Lemen, March 20, 1986
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BENZENE
CARCINOGENS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EPIDEMIOLOGY
HEMIC DISEASES
HYDROCARBONS
IMMUNE SYSTEM DISEASES
LEUKEMIA
MATHEMATICS
MAXIMUM PERMISSIBLE EXPOSURE
MORTALITY
NEOPLASMS
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
PERSONNEL
REGRESSION ANALYSIS
RISK ASSESSMENT
SAFETY STANDARDS
STANDARDS
STATISTICS
TOXICITY