Role of postoperative irradiation in carcinoma of the breast
Conference
·
· Cancer; (United States)
OSTI ID:7187442
Chest wall and regional nodal recurrences, and survival following postmastectomy radiation therapy, were analyzed in 352 patients. Patients with T1 and T2 central and medial breast lesions, negative axillary nodal findings, and no evidence of skin or chest wall extension received irradiation to the peripheral lymphatics alone. There were no chest wall recurrences among these patients. The remainder of the patients, including those with axillary nodal involvement, regardless of the site of the primary breast lesion received irradiation by a three-field technique directed to both chest wall and regional nodes. The chest wall recurrence rate was 1.9 percent when axillary nodes were negative for metastatic disease, 1.3 percent when the axillary nodes showed less than 50 percent positivity, and 14.2 percent when axillary nodes showed greater than 50 percent involvement. The overall chest wall recurrence rate was 5.1 percent. A possible mechanism of chest wall recurrence is discussed. Cumulative 5-year survival for stage I is 76 percent, for stage II, 79 percent, and for stage III, 57 percent. If chemotherapy proves to be effective in controlling distant microscopic disease local control may become an equally critical issue in long-term survival of patients with breast carcinoma.
- Research Organization:
- Joint Center for Radiation Therapy, Boston
- OSTI ID:
- 7187442
- Conference Information:
- Journal Name: Cancer; (United States) Journal Volume: 37:6
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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BIOLOGICAL RADIATION EFFECTS
BODY
BONE FRACTURES
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GLANDS
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PATHOLOGICAL CHANGES
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RADIATION EFFECTS
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SKELETAL DISEASES
SKELETON
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE FRACTURES
CARCINOMAS
DISEASES
FIBROSIS
GLANDS
INJURIES
LUNGS
MAMMARY GLANDS
MEDICINE
NECROSIS
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SIDE EFFECTS
SKELETAL DISEASES
SKELETON
THERAPY