Monitoring pulmonary vascular permeability using radiolabeled transferrin

Journal Article · Fri Jul 01 04:00:00 EDT 1988 · J. Thorac. Imaging.; (United States)

DOI:https://doi.org/10.1097/00005382-198807000-00009· OSTI ID:7187295

Basran, G S; Hardy, J G

A simple, noninvasive technique for monitoring pulmonary vascular permeability in patients in critical care units is discussed. High vascular permeability is observed in patients with clinically defined adult respiratory distress syndrome (ARDS) but not in patients with hydrostatic pulmonary edema or in patients with minor pulmonary insults who are considered to be at risk of developing ARDS. The technique has been used in the field of therapeutics and pharmacology to test the effects of the putative antipermeability agents methylprednisolone and terbutaline sulfate. There appears to be a good correlation between the acute inhibitory effect of either drug on transferrin exudation and patient prognosis. Thus, a byproduct of such drug studies may be an index of survival in patients with established ARDS.

• Research Organization: Rotherham District General Hospital, South Yorkshire (England)
• OSTI ID: 7187295
• Journal Information: J. Thorac. Imaging.; (United States), Journal Name: J. Thorac. Imaging.; (United States) Journal Issue: 3 Vol. 3:3; ISSN JTIME
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD VESSELS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
DIAGNOSIS
DISEASES
ERYTHROCYTES
GLOBULINS
GLOBULINS-BETA
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MATERIALS
METALLOPROTEINS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PERMEABILITY
PROTEINS
RESPIRATORY SYSTEM DISEASES
SURVIVAL CURVES
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
TRANSFERRIN