Stimulation of hepatic glycogenolysis by phorbol-12-myristate-13-acetate
Journal Article
·
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:7186881
In isolated perfused rat livers, infusion of phorbol-12-myristate-13-acetate (150 nM) resulted in a three-fold stimulation of the rate of glucose production. This response was maximal at perfusate phorbol ester concentration of 150 nM, and was significantly diminished at higher concentrations of the phorbol ester (e.g. 300 nM). Stimulation of glycogenolysis by phorbol ester was greatly decreased in livers perfused infusion into livers perfused with calcium-free medium. Phorbol-12-myristate-13-acetate infusion into livers perfused in the absence of calcium did not result in calcium efflux from the livers. Additionally, in hepatocytes isolated from livers of fed rats neither the phorbol ester nor 1-oleoyl-2-acetyl-rac-glycerol, stimulated the rate of glucose production. This last result along with the observations that in isolated perfused rat livers, phorbol-12-myristate-13-acetate increases portal pressure, and decreases oxygen consumption suggests that stimulation of hepatic glycogenolysis by phorbol ester is the result of increased vasoconstriction, and is not a consequence of a direct effect of the phorbol ester on liver parenchymal cells.
- Research Organization:
- Univ. of Tennessee, Memphis
- OSTI ID:
- 7186881
- Report Number(s):
- CONF-8606151-
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Vol. 45:6; ISSN FEPRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ALDEHYDES
ANIMALS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CARBOHYDRATES
CARCINOGENS
DIGESTIVE SYSTEM
ESTERS
GLANDS
GLUCOSE
GLYCEROL
HEXOSES
HYDROXY COMPOUNDS
LIVER
MAMMALS
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
PERFUSED ORGANS
PHORBOL ESTERS
RATS
RODENTS
SACCHARIDES
SYNTHESIS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ALDEHYDES
ANIMALS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CARBOHYDRATES
CARCINOGENS
DIGESTIVE SYSTEM
ESTERS
GLANDS
GLUCOSE
GLYCEROL
HEXOSES
HYDROXY COMPOUNDS
LIVER
MAMMALS
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
PERFUSED ORGANS
PHORBOL ESTERS
RATS
RODENTS
SACCHARIDES
SYNTHESIS
VERTEBRATES