Biventricular dynamics during quantitated anteroseptal infarction in the porcine heart

Journal Article · Sat Nov 01 04:00:00 EST 1975 · Am. J. Cardiol.; (United States)

DOI:https://doi.org/10.1016/0002-9149(75)90458-0· OSTI ID:7184684

Brooks, H; Al-Sadir, J; Schwartz, J; Rich, B; Harper, P; Resnekov, L; Dellenbauch, J

The porcine heart has been shown to have close anatomic similarity to the human heart and was used as the experimental model in this study to gain further understanding of the early responses of both ventricles during acute anteroseptal myocardial infarction. High fidelity pressure and flow data were measured and multiple preejection and ejection variables were calculated for both ventricles. Infarct weight and distribution in both ventricles were quantitated. The standard infarction resulted from single stage ligation of the left anterior descending coronary artery just beyond its midpoint and second left ventricular branch. It comprised an average of 15.8 percent of total ventricular myocardium with an infarct/perfused ratio of 0.62 and a periinfarction transition zone of 7.5 mm, and involved significant portions of both ventricles and the interventricular septum. Performance characteristics of both ventricles were altered significantly by anteroseptal infarction and involved all phases of contraction--end-diastole, isovolumic systole and ventricular ejection. Although contractile alterations in the right ventricle were significant, they were somewhat delayed, yielding relatively low correlation coefficients with analogous left ventricular contractile indexes. These correlations became quite distinct during specific ventricular stresses. Comparison of anterolateral and anteroseptal infarction, matched in terms of infarct size, indicated that the right ventricular changes in the latter were related to direct involvement of the right ventricular free wall and septum rather than secondary to left ventricular alterations.

• Research Organization: Univ. of Chicago
• OSTI ID: 7184684
• Journal Information: Am. J. Cardiol.; (United States), Journal Name: Am. J. Cardiol.; (United States) Vol. 36; ISSN AJCDA
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
551000* -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DISEASES
DOMESTIC ANIMALS
HEART
MAMMALS
MYOCARDIAL INFARCTION
ORGANS
PHYSIOLOGY
SWINE
VERTEBRATES