Red blood cells protect endothelial cells against H/sub 2/O/sub 2/-mediated but not hyperoxia-induced damage

Journal Article · Fri Jul 01 00:00:00 EDT 1988 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-188-42741· OSTI ID:7183863

Tsan, M F; White, J E

We studied the effect of intact red blood cells on the exogenous H/sub 2/O/sub 2/-mediated damage as well as on the hyperoxia-induced injury of cultured endothelial cells. Red blood cells protected endothelial cells against H/sub 2/O/sub 2/-mediated injury efficiently, but had no effect on the hyperoxia-induced damage. Failure of red blood cells to protect endothelial cells against hyperoxia-induced injury was not due to hemolysis. Furthermore, hyperoxia-exposed red blood cells were still capable of protecting endothelial cells against H/sub 2/O/sub 2/-mediated damage.

• Research Organization: Veterans Administration Medical Center, Albany, NY (USA)
• OSTI ID: 7183863
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 188:3; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
ANOXIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CATTLE
CELL CULTURES
DOMESTIC ANIMALS
ELEMENTS
ENDOTHELIUM
ERYTHROCYTES
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
INJURIES
MAMMALS
MATERIALS
NONMETALS
OXYGEN
OXYGEN COMPOUNDS
PEROXIDES
RUMINANTS
TISSUES
TOXICITY
VERTEBRATES