Halogenated hydrocarbon pollutants: biologic and toxic effects
Thesis/Dissertation
·
OSTI ID:7183665
The effects of various halogenated hydrocarbon pollutants on hepatic microsomal drug and steroid metabolizing enzymes were determined in neonatal, immature and adult Long Evans rats. The teratogenic and/or fetotoxic effects of polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin were also examined using the C57BL/6N mouse. The organochlorine pesticides p,p'-DDE, heptachlor, chlordane, toxaphene and dieldrin, like phenobarbital (PB), induced hepatic microsomal formation of the 4,5-dihydrodiol, 9- and 3-hydroxy metabolites of benzo(a)pyrene and induced hepatic microsomal testosterone 16..cap alpha.. and 16..beta..-hydroxylase in immature male Long Evans rats.
- Research Organization:
- Texas A and M Univ., College Station (USA)
- OSTI ID:
- 7183665
- Country of Publication:
- United States
- Language:
- English
Similar Records
Great Lakes water quality initiative criteria documents for the protection of human health (February 1993 draft)
Effects of embryonic and adult exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic microsomal testosterone hydroxylase activities in great blue herons (Ardea herodias)
Organochlorine residues in finfish from Maryland waters 1976-1980
Technical Report
·
Sun Jan 31 23:00:00 EST 1993
·
OSTI ID:6502089
Effects of embryonic and adult exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic microsomal testosterone hydroxylase activities in great blue herons (Ardea herodias)
Journal Article
·
Sun Jun 01 00:00:00 EDT 1997
· Environmental Toxicology and Chemistry
·
OSTI ID:514610
Organochlorine residues in finfish from Maryland waters 1976-1980
Journal Article
·
Sat Nov 30 23:00:00 EST 1985
· J. Environ. Sci. Health, Part B; (United States)
·
OSTI ID:5735981
Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANDROGENS
ANDROSTANES
ANIMALS
AROMATICS
BENZOPYRENE
BODY
CELL CONSTITUENTS
CHLORINATED AROMATIC HYDROCARBONS
CONDENSED AROMATICS
DIGESTIVE SYSTEM
DIOXIN
ENZYME ACTIVITY
ENZYMES
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROCARBONS
HYDROXY COMPOUNDS
HYDROXYLASES
KETONES
LIVER
MAMMALS
METABOLISM
MICROSOMES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
ORGANS
OXIDOREDUCTASES
PESTICIDES
RATS
RODENTS
STEROID HORMONES
STEROIDS
TERATOGENESIS
TESTOSTERONE
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANDROGENS
ANDROSTANES
ANIMALS
AROMATICS
BENZOPYRENE
BODY
CELL CONSTITUENTS
CHLORINATED AROMATIC HYDROCARBONS
CONDENSED AROMATICS
DIGESTIVE SYSTEM
DIOXIN
ENZYME ACTIVITY
ENZYMES
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROCARBONS
HYDROXY COMPOUNDS
HYDROXYLASES
KETONES
LIVER
MAMMALS
METABOLISM
MICROSOMES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
ORGANS
OXIDOREDUCTASES
PESTICIDES
RATS
RODENTS
STEROID HORMONES
STEROIDS
TERATOGENESIS
TESTOSTERONE
TOXICITY
VERTEBRATES