Synthesis and properties of 5-(5-Nitro-2-furyl) thiazolines-

Journal Article · Tue Apr 01 04:00:00 EST 1986 · Chem. Heterocycl. Compd. (Engl. Transl.); (United States)

OSTI ID:7170088

Ksova, E B; Krapivin, G D; Kul'nevich, V G

The reactions of 2-amino-4-methyl-5-(5-nitro-2-furyl) thiazole with excess methyl iodide leads to 3,4-dimethyl-2-methylamino-5-(5-nitro-2-furyl) thiazolium iodide, which is converted to 2-imino-3,4-dimethyl-5(-nitro-2-furyl) thiazoline under the influence of bases. The iminothiazoline structure was proved by comparison of the spectral characteristics of its acetyl derivative and the isomeric 2-(N-acetyl-Nmethyl) amino-4-methyl-5-(5-nitro-2-furyl) thiazole. The pKa values of 2-amino-4methyl-5-(5-nitro-2-furyl) thiazole and 3,4-dimethyl-2-imino-5-(5-nitro-2-furyl)thiazoline were determined, and the constant of the aminothiazole-iminothiazoline tautomeric equilibrium was calculated.

• Research Organization: Kusnodar Polytechnic Institute, Krasnodar
• OSTI ID: 7170088
• Journal Information: Chem. Heterocycl. Compd. (Engl. Transl.); (United States), Journal Name: Chem. Heterocycl. Compd. (Engl. Transl.); (United States) Vol. 21:10; ISSN CHCCA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400201* -- Chemical & Physicochemical Properties
ABSORPTION SPECTRA
AZOLES
CHEMICAL PROPERTIES
CHEMICAL REACTION KINETICS
CHEMICAL REACTION YIELD
HALOGENATED ALIPHATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
IODINATED ALIPHATIC HYDROCARBONS
KINETICS
MASS SPECTRA
METHYL IODIDE
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
QUANTITY RATIO
REACTION KINETICS
SPECTRA
SYNTHESIS
THIAZOLES
YIELDS