Half-life of polychlorinated biphenyls in occupationally exposed workers

Journal Article · Tue Oct 31 23:00:00 EST 1989 · Archives of Environmental Health; (USA)

DOI:https://doi.org/10.1080/00039896.1989.9935905· OSTI ID:7167246

Phillips, D L; Smith, A B; Burse, V W; Steele, G K; Needham, L L; Hannon, W H ^[1]

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1. Centers for Disease Control, Atlanta, GA (USA)

In 1977 and 1985, serum polychlorinated biphenyl (PCB) concentrations were determined for 58 workers in a Bloomington, Indiana, factory that used polychlorinated biphenyls (PCBs) in capacitor manufacture until 1977. Less chlorinated PCBs were quantitated as Aroclor 1242, and more highly chlorinated PCBs were quantitated as Aroclor 1254. The median half-life was 2.6 y for Aroclor 1242 and 4.8 y for Aroclor 1254. However, the half-life varied inversely with the initial serum concentration. This pattern may be a result of continued low-level exposure, variation in the time of exposure, or enzyme induction by PCBs.

• OSTI ID: 7167246
• Journal Information: Archives of Environmental Health; (USA), Journal Name: Archives of Environmental Health; (USA) Vol. 44:6; ISSN AEHLA; ISSN 0003-9896
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BIOLOGICAL HALF-LIFE
CHLORINATED AROMATIC HYDROCARBONS
ENZYME INDUCTION
FEDERAL REGION V
GENE REGULATION
HALOGENATED AROMATIC HYDROCARBONS
INDIANA
METABOLISM
NORTH AMERICA
OCCUPATIONAL EXPOSURE
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PERSONNEL
USA