Teratogenesis of polychlorocycloalkane insecticides in chicken embryos resulting from their interactions at the convulsant recognition sites of the GABA (pro)receptor complex

Journal Article · Mon May 01 04:00:00 EDT 1989 · Bulletin of Environmental Contamination and Toxicology; (USA)

DOI:https://doi.org/10.1007/BF01700392· OSTI ID:7167237

Seifert, J ^[1]

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1. Univ. of Hawaii, Honolulu (USA)

There is an increasing concern for the effects of toxicants expressed during embryonic development. This paper considers the teratogenicity of polychlorocycloalkane insecticides. They are neurotoxicants which act at the convulsant recognition site(s) of the GABA receptor-chloride ionophore and antagonize GABA-mediated inhibitory neurotransmission. This study uses the chicken embryo as a model organism. It focuses on malformations related to interactions of polychlorocycloalkane insecticides with the convulsant recognition sites in the brain. Information provided by this study is important for investigations on the teratogenicity of insecticidal GABA antagonists in mammals.

• OSTI ID: 7167237
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (USA), Journal Name: Bulletin of Environmental Contamination and Toxicology; (USA) Vol. 42:5; ISSN 0007-4861; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
AMINOBUTYRIC ACID
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIRDS
BODY
BRAIN
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CELL MEMBRANES
CENTRAL NERVOUS SYSTEM
CHEMICAL ANALYSIS
CHICKENS
CHLORINATED AROMATIC HYDROCARBONS
CONGENITAL MALFORMATIONS
DRUGS
EMBRYOS
FOWL
HALOGENATED AROMATIC HYDROCARBONS
HYDROGEN COMPOUNDS
INSECTICIDES
ISOTOPE APPLICATIONS
MALFORMATIONS
MEMBRANE PROTEINS
MEMBRANES
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PESTICIDES
PROTEINS
QUANTITATIVE CHEMICAL ANALYSIS
RADIORECEPTOR ASSAY
RECEPTORS
TERATOGENESIS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES