Induction of hepatic cytochrome P-450 activity in wild cotton rats (Sigmodon hispidus) by phenobarbital and 3-methylcholanthrene

Journal Article · Mon May 01 04:00:00 EDT 1989 · Bulletin of Environmental Contamination and Toxicology; (USA)

DOI:https://doi.org/10.1007/BF01700393· OSTI ID:7167234

Elangbam, C S; Qualls, Jr, C W; Bauduy, M ^[1]

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1. Oklahoma State Univ., Stillwater (USA)

Wild cotton rats (Sigmodon hispidus) are ubiquitous throughout the Southeast quadrant of the United States, easy to capture, have a generation interval of less than one year and a limited range of movement (less than one hectare). This species may prove to be an excellent model for monitoring environmental contamination. Traditionally, cytochrome P-450 inducing agents are grouped into two classes. One, represented by phenobarbital, induces P-450b and P-450e; the other, represented by 3-methylcholanthrene, induces P-450c and P-450d isoenzymes. The types and amounts of cytochrome P-450 vary among species, organs, health status, sex, and stress of the animal. If the levels of cytochrome P-450 of wild cotton rats are to be used in monitoring environmental pollution, it is necessary to characterize the inducibility and concentration of cytochrome P-450 in this species. This study was designed to determine the concentration and inducibility of cytochrome P-450 in the livers of cotton rats after intraperitoneal (ip) administration of phenobarbital and 3-methylcholanthrene.

• OSTI ID: 7167234
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (USA), Journal Name: Bulletin of Environmental Contamination and Toxicology; (USA) Vol. 42:5; ISSN 0007-4861; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

3-METHYLCHOLANTHRENE
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANESTHETICS
ANIMALS
ANTICONVULSANTS
AROMATICS
AZINES
BARBITURATES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BODY
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHEMISTRY
CYTOCHROMES
DIGESTIVE SYSTEM
DRUGS
ENZYME ACTIVITY
ENZYME INDUCTION
GENE REGULATION
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
HYPNOTICS AND SEDATIVES
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
LIVER
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PHENOBARBITAL
PIGMENTS
POLYCYCLIC AROMATIC HYDROCARBONS
PREGNANCY
PROTEINS
PYRIMIDINES
RATS
RODENTS
SEX DEPENDENCE
VERTEBRATES