Effects of ACTH on corticosteroid and progesterone levels in female baboons depending on the phase of the menstrual cycle

Journal Article · Wed Jan 01 00:00:00 EST 1986 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

OSTI ID:7166195

Todua, T N; Goncharov, N P; Katsiya, G V; Lapin, B A; Vorontsov, V I

To study the effect of ACTH on the endocrine function of steroid producing glands depending on the level of sex hormones in the body, a comparative study of the dynamics of steroid hormones in the follicular and luteal phases of the menstrual cycle in response to a standard does of ACTH was undertaken in experiments on hamadryad baboons. Concentrations of corticosterone, 11-deoxycortisol, and progesterone were determined in duplicate samples of plasma by radioimmunoassay. It is shown that the sensitivity of the adrenals to a single injection of ACTH is independent of the phase of the menstrual cycle and the inhibitory effects of ACTH on progesterone secretion is exhibited only in the presence of an actively functioning corpus luteus of the ovary.

• Research Organization: Academy of Medical Screnies of the USSR, Sukhumi
• OSTI ID: 7166195
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 100:8
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ACTH
BIOLOGICAL EFFECTS
APES
ESTROUS CYCLE
ENDOCRINE GLANDS
BIOLOGICAL FUNCTIONS
RADIOIMMUNOASSAY
BLOOD PLASMA
CORTICOSTEROIDS
DOSE-RESPONSE RELATIONSHIPS
INTRAVENOUS INJECTION
METABOLISM
OVARIES
OVULATION
PROGESTERONE
RETENTION
SECRETION
ADRENAL HORMONES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
FEMALE GENITALS
FUNCTIONS
GLANDS
GONADS
HORMONES
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
INJECTION
INTAKE
ISOTOPE APPLICATIONS
KETONES
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
PREGNANES
PRIMATES
RADIOASSAY
RADIOIMMUNOLOGY
STEROID HORMONES
STEROIDS
TRACER TECHNIQUES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques