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Effects of ACTH on corticosteroid and progesterone levels in female baboons depending on the phase of the menstrual cycle

Journal Article · · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
OSTI ID:7166195
; ; ; ;

To study the effect of ACTH on the endocrine function of steroid producing glands depending on the level of sex hormones in the body, a comparative study of the dynamics of steroid hormones in the follicular and luteal phases of the menstrual cycle in response to a standard does of ACTH was undertaken in experiments on hamadryad baboons. Concentrations of corticosterone, 11-deoxycortisol, and progesterone were determined in duplicate samples of plasma by radioimmunoassay. It is shown that the sensitivity of the adrenals to a single injection of ACTH is independent of the phase of the menstrual cycle and the inhibitory effects of ACTH on progesterone secretion is exhibited only in the presence of an actively functioning corpus luteus of the ovary.

Research Organization:
Academy of Medical Screnies of the USSR, Sukhumi
OSTI ID:
7166195
Journal Information:
Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 100:8; ISSN BEXBA
Country of Publication:
United States
Language:
English

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Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ACTH
ADRENAL HORMONES
ANIMALS
APES
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CORTICOSTEROIDS
DOSE-RESPONSE RELATIONSHIPS
ENDOCRINE GLANDS
ESTROUS CYCLE
FEMALE GENITALS
FUNCTIONS
GLANDS
GONADS
HORMONES
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
KETONES
MAMMALS
MATERIALS
METABOLISM
ORGANIC COMPOUNDS
ORGANS
OVARIES
OVULATION
PEPTIDE HORMONES
PITUITARY HORMONES
PREGNANES
PRIMATES
PROGESTERONE
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RETENTION
SECRETION
STEROID HORMONES
STEROIDS
TRACER TECHNIQUES
VERTEBRATES