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Title: Establishing the diagnosis of benign familial hematuria: the importance of examining the urine sediment of family members

Abstract

Patients with microscopic hematuria are generally referred for urologic investigation. The authors describe 30 patients with normal renal function referred to our clinic during the years 1970 through 1987 for evaluation of hematuria, usually microscopic, in whom prior urologic and radiological studies had failed to determine the cause of bleeding. Urinary sediment from the patients and first-degree relatives revealed hemoglobin and red blood cell casts; the inheritance pattern was consistent with autosomal dominant transmission. During follow-up for up to 18 years, renal function remained normal, thus confirming the diagnosis of benign familial hematuria. Immunoglobulin A nephropathy and Alport's syndrome were less common than benign familial hematuria and could be differentiated from it by history, physical examination, and routine laboratory testing. Since benign familial hematuria is a common disorder in adults with hematuria and normal renal function, urinary sediment from patients and family members should be examined before extensive urologic and radiological procedures are performed.

Authors:
; ;
Publication Date:
Research Org.:
Medical College of Wisconsin, Milwaukee (USA)
OSTI Identifier:
7164825
Resource Type:
Journal Article
Journal Name:
JAMA, J. Am. Med. Assoc.; (United States)
Additional Journal Information:
Journal Volume: 259:15
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; HEREDITARY DISEASES; PATHOGENESIS; UROGENITAL SYSTEM DISEASES; AGE DEPENDENCE; BLOOD PRESSURE; ERYTHROCYTES; HEMOGLOBIN; HEMORRHAGE; PATIENTS; SEX DEPENDENCE; URINE; WISCONSIN; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOXYLIC ACIDS; DISEASES; FEDERAL REGION V; GLOBIN; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; MATERIALS; NORTH AMERICA; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PATHOLOGICAL CHANGES; PIGMENTS; PORPHYRINS; PROTEINS; SYMPTOMS; USA; WASTES; 550200* - Biochemistry

Citation Formats

Blumenthal, S.S., Fritsche, C., and Lemann, J. Jr. Establishing the diagnosis of benign familial hematuria: the importance of examining the urine sediment of family members. United States: N. p., 1988. Web. doi:10.1001/jama.1988.03720150039033.
Blumenthal, S.S., Fritsche, C., & Lemann, J. Jr. Establishing the diagnosis of benign familial hematuria: the importance of examining the urine sediment of family members. United States. doi:10.1001/jama.1988.03720150039033.
Blumenthal, S.S., Fritsche, C., and Lemann, J. Jr. Fri . "Establishing the diagnosis of benign familial hematuria: the importance of examining the urine sediment of family members". United States. doi:10.1001/jama.1988.03720150039033.
@article{osti_7164825,
title = {Establishing the diagnosis of benign familial hematuria: the importance of examining the urine sediment of family members},
author = {Blumenthal, S.S. and Fritsche, C. and Lemann, J. Jr},
abstractNote = {Patients with microscopic hematuria are generally referred for urologic investigation. The authors describe 30 patients with normal renal function referred to our clinic during the years 1970 through 1987 for evaluation of hematuria, usually microscopic, in whom prior urologic and radiological studies had failed to determine the cause of bleeding. Urinary sediment from the patients and first-degree relatives revealed hemoglobin and red blood cell casts; the inheritance pattern was consistent with autosomal dominant transmission. During follow-up for up to 18 years, renal function remained normal, thus confirming the diagnosis of benign familial hematuria. Immunoglobulin A nephropathy and Alport's syndrome were less common than benign familial hematuria and could be differentiated from it by history, physical examination, and routine laboratory testing. Since benign familial hematuria is a common disorder in adults with hematuria and normal renal function, urinary sediment from patients and family members should be examined before extensive urologic and radiological procedures are performed.},
doi = {10.1001/jama.1988.03720150039033},
journal = {JAMA, J. Am. Med. Assoc.; (United States)},
number = ,
volume = 259:15,
place = {United States},
year = {1988},
month = {4}
}