Investigation into the combined effects of X-irradiation and 3MHz ultrasound-induced hyperthermia on pig skin

Journal Article · Sun May 01 04:00:00 EDT 1988 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(88)90023-5· OSTI ID:7151942

ter Haar, G; Hopewell, J W

The thermal enhancement of radiation-induced damage in pig skin has been investigated. Heating at 43 degrees C for 60 min was produced by a scanned 3MHz ultrasound transducer, immediately after single doses of X rays. The ED50 values for the dermal reactions of dusky/mauve erythema and necrosis after irradiation alone were 18.6 +/- 0.5 Gy and 20.5 +/- 0.4 Gy, respectively. The reduction in the ED50 values to 15.3 +/- 0.4 Gy and 17.7 +/- 0.5 Gy after irradiation plus heating was significant and suggested a thermal enhancement ratio (TER) of between 1.15 and 1.22. These TER values were within the range obtained in both pig and rat skin using other dry heating methods. This would suggest that the non-thermal effects of ultrasound do not influence the thermal enhancement of x-irradiation damage.

• Research Organization: Institute of Cancer Research, Sutton, Surrey (England)
• OSTI ID: 7151942
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 14:5; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY TEMPERATURE
DOMESTIC ANIMALS
ELECTROMAGNETIC RADIATION
ENERGY
HEAT
HYPERTHERMIA
INJURIES
IONIZING RADIATIONS
MAMMALS
ORGANS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
SKIN
SWINE
SYNERGISM
ULTRASONOGRAPHY
VERTEBRATES
X RADIATION