Synthesis and in-vivo detection of boronated compounds for use in BNCT
The primary objective of the DOE Program at the University of Tennessee Biomedical Imaging Center is the development of new technology to detect boron compounds in-vivo. The research focuses on the development of multinuclear magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques for verifying and measuring BNCT agents in-vivo. A small but significant portion of the effort is directed toward the design of boron-containing neutron-capture-therapy agents. The UT -- DOE program is unique in that it has access to two state-of-the-art multinuclear magnetic resonance imaging units housed in the Biomedical Imaging Center at the University of Tennessee Medical Center at Knoxville. Included in this report are two sections describing research accomplishments in multinuclear magnetic resonance imaging and synthesis of potential BNCT agents.
- Research Organization:
- Tennessee Univ. Hospital, Knoxville, TN (USA). Dept. of Radiology
- Sponsoring Organization:
- DOE/ER
- DOE Contract Number:
- FG05-89ER60892
- OSTI ID:
- 7151243
- Report Number(s):
- DOE/ER/60892-1; ON: DE90008974; TRN: 90-010197
- Country of Publication:
- United States
- Language:
- English
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Synthesis and in-vivo detection of boronated compounds for use in BNCT
Synthesis and in-vivo detection of boronated compounds for use in BNCT. Comprehensive progress report, August 1, 1989--July 31, 1992
Related Subjects
BORON COMPOUNDS
CHEMICAL PREPARATION
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL LOCALIZATION
COMPUTERIZED TOMOGRAPHY
GADOLINIUM
LABELLED COMPOUNDS
LIPOSOMES
NEOPLASMS
NEUTRON CAPTURE THERAPY
NEUTRON SOURCE FACILITIES
NMR IMAGING
NMR SPECTRA
PATIENTS
PROGRESS REPORT
RADIOISOTOPES
RADIOPHARMACEUTICALS
CELL CONSTITUENTS
DIAGNOSTIC TECHNIQUES
DISEASES
DOCUMENT TYPES
DRUGS
ELEMENTS
ISOTOPES
KINETICS
MEDICINE
METALS
NEUTRON THERAPY
NUCLEAR MEDICINE
ORGANOIDS
RADIOLOGY
RADIOTHERAPY
RARE EARTHS
REACTION KINETICS
SPECTRA
SYNTHESIS
THERAPY
TOMOGRAPHY
550602* - Medicine- External Radiation in Diagnostics- (1980-)
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)