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Title: Synthesis of alpha-amino acids

Abstract

A method is described for synthesizing alpha amino acids proceeding through novel intermediates of the formulas: R[sub 1]R[sub 2]C(OSOCl)CN, R[sub 1]R[sub 2]C(Cl)CN and [R[sub 1]R[sub 2]C(CN)O][sub 2]SO wherein R[sub 1] and R[sub 2] are each selected from hydrogen monovalent substituted and unsubstituted hydrocarbon radicals of 1 to 10 carbon atoms. The use of these intermediates allows the synthesis steps to be exothermic and results in an overall synthesis method which is faster than the synthesis methods of the prior art. No Drawings

Inventors:
Publication Date:
OSTI Identifier:
7145019
Patent Number(s):
US 4370493; A
Application Number:
PPN: US 6-278106
Assignee:
Secretary of Energy, Washington, DC (United States) PTO; EDB-94-125897
DOE Contract Number:
W-7405-ENG-48
Resource Type:
Patent
Resource Relation:
Patent File Date: 29 Jun 1981
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; AMINO ACIDS; SYNTHESIS; BIOCHEMISTRY; CHEMICAL BONDS; CHEMICAL COMPOSITION; CARBOXYLIC ACIDS; CHEMISTRY; ORGANIC ACIDS; ORGANIC COMPOUNDS; 550200* - Biochemistry

Citation Formats

Davis, J.W. Jr. Synthesis of alpha-amino acids. United States: N. p., 1983. Web.
Davis, J.W. Jr. Synthesis of alpha-amino acids. United States.
Davis, J.W. Jr. 1983. "Synthesis of alpha-amino acids". United States. doi:.
@article{osti_7145019,
title = {Synthesis of alpha-amino acids},
author = {Davis, J.W. Jr.},
abstractNote = {A method is described for synthesizing alpha amino acids proceeding through novel intermediates of the formulas: R[sub 1]R[sub 2]C(OSOCl)CN, R[sub 1]R[sub 2]C(Cl)CN and [R[sub 1]R[sub 2]C(CN)O][sub 2]SO wherein R[sub 1] and R[sub 2] are each selected from hydrogen monovalent substituted and unsubstituted hydrocarbon radicals of 1 to 10 carbon atoms. The use of these intermediates allows the synthesis steps to be exothermic and results in an overall synthesis method which is faster than the synthesis methods of the prior art. No Drawings},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = 1983,
month = 1
}
  • A method for synthesizing alpha amino acids proceding through novel intermediates of the formulas: R.sub.1 R.sub.2 C(OSOCl)CN, R.sub.1 R.sub.2 C(Cl)CN and [R.sub.1 R.sub.2 C(CN)O].sub.2 SO wherein R.sub.1 and R.sub.2 are each selected from hydrogen monovalent substituted and unsubstituted hydrocarbon radicals of 1 to 10 carbon atoms. The use of these intermediates allows the synthesis steps to be exothermic and results in an overall synthesis method which is faster than the snythesis methods of the prior art.
  • A method for synthesizing alpha amino acids proceding through novel intermediates of the formulas: R.sub.1 R.sub.2 C(OSOCl)CN, R.sub.1 R.sub.2 C(Cl)CN and [R.sub.1 R.sub.2 C(CN)O].sub.2 SO wherein R.sub.1 and R.sub.2 are each selected from hydrogen monovalent substituted and unsubstituted hydrocarbon radicals of 1 to 12 carbon atoms. The use of these intermediates allows the synthesis steps to be exothermic and results in an overall synthesis method which is faster than the synthesis methods of the prior art.
  • A method for synthesizing alpha amino acids proceeding through novel intermediates of the formulas: R.sub.1 R.sub.2 C(OSOCl)CN, R.sub.1 R.sub.2 C(Cl)CN and [R.sub.1 R.sub.2 C(CN)O].sub.2 SO wherein R.sub.1 and R.sub.2 are each selected from hydrogen monovalent substituted and unsubstituted hydrocarbon radicals of 1 to 12 carbon atoms. The use of these intermediates allows the synthesis steps to be exothermic and results in an overall synthesis method which is faster than the synthesis methods of the prior art.
  • A method for synthesizing alpha amino acids proceeding through novel intermediates of the formulas: R/sub 1/R/sub 2/C(Osoc/sub l/)C/sub n/, R/sub 1/R/sub 2/C(C/sub l/)C/sub n/ and (R/sub 1/R/sub 2/C(C/sub n/)O)/sub 2/SO wherein R/sub 1/ and R/sub 2/ are each selected from hydrogen monovalent substituted and unsubstituted hydrocarbon radicals of 1 to 12 carbon atoms. The use of these intermediates allows the synthesis steps to be exothermic and results in an overall synthesis method which is faster than the synthesis methods of the prior art.
  • A method is described for synthesizing alpha amino acids proceeding through novel intermediates of the formulas: R/sub 1/R/sub 2/C(OSOCl)C/sub n/, R/sub 1/R/sub 2/C(Cl)C/sub n/ and (R/sub 1/R/sub 2/C(C/sub n/)O)2SO wherein R/sub 1/ and R/sub 2/ are each selected from hydrogen monovalent substituted and unsubstituted hydrocarbon radicals of 1 to 12 carbon atoms. The use of these intermediates allows the synthesis steps to be exothermic and results in an overall synthesis method which is faster than the synthesis methods of the prior art.