Structurally divergent human T cell receptor. gamma. proteins encoded by distinct C. gamma. genes

Journal Article · Fri Jul 03 04:00:00 EDT 1987 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.2955517· OSTI ID:7143870

Krangel, M S; Band, H; Hata, S; McLean, J; Brenner, M B

The human T cell receptor (TCR) ..gamma.. polypeptide occurs in structurally distinct forms on certain peripheral blood T lymphocytes. Complementary DNA clones representing the transcripts of functionally rearranged TCR ..gamma.. genes in these cells have been analyzed. The expression of a disulfide-linked and a nondisulfide-linked form of TCR ..gamma.. correlates with the use of the C..gamma..1 and C..gamma..2 constant-region gene segments, respectively. Variability in TCR ..gamma.. polypeptide and disulfide linkage is determined by the number of copies and the sequence of a repeated segment of the constant region. Thus, C..gamma..1 and C..gamma..2 are used to generate structurally distinct, yet functional, T3-associated receptor complexes on peripheral blood lymphocytes. Tryptic peptide mapping suggests that the T3-associated TCR ..gamma.. and delta peptides in the nondisulfide-linked form are distinct.

• Research Organization: Harvard Medical School, Boston (USA)
• OSTI ID: 7143870
• Journal Information: Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 237; ISSN SCIEA
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
AMINO ACID SEQUENCE
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CLONING
CONNECTIVE TISSUE CELLS
DNA-CLONING
GENES
GENETIC MAPPING
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MAPPING
MATERIALS
MEMBRANE PROTEINS
MOLECULAR STRUCTURE
ORGANIC COMPOUNDS
PEPTIDES
POLYPEPTIDES
PRIMATES
PROTEINS
RECEPTORS
SOMATIC CELLS
VERTEBRATES