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Synthesis of (gamma-/sup 32/P)thiamine triphosphate

Journal Article · · Anal. Biochem.; (United States)
We developed a novel chemical synthesis of thiamine triphosphate which allows us to incorporate /sup 32/P in the gamma position. The reaction is based on the condensation of (/sup 32/P)orthophosphoric acid and thiamine diphosphate in the presence of ethyl chloroformate. After purification by two ion-exchange purification steps, the thiamine derivative has a specific radioactivity of 10 Ci/mmol. The average final yield synthesis is about 10%.
Research Organization:
Universite de Liege (Belgium)
OSTI ID:
7140937
Journal Information:
Anal. Biochem.; (United States), Journal Name: Anal. Biochem.; (United States) Vol. 169:2; ISSN ANBCA
Country of Publication:
United States
Language:
English